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Are Antibiotics Giving Kids Kidney Stones?

July 24, 2023 By Richard C. Young

By Marcin Balcerzak @ Shutterstock.com

On his blog, Mercola.com, Dr. Joseph Mercola discusses research that found a link between oral antibiotics and kidney stones in children. He writes:

According to research1 published in the Journal of the American Society of Nephrology (JASN) in 2018, oral antibiotics are a risk factor for kidney stones. Health records for 13 million children and adults in the U.K. were reviewed, showing that exposure to five classes of oral antibiotics were associated with kidney stones within three to 12 months post-use. The adjusted odds ratio of kidney stones was:

  • 1.27 for broad-spectrum penicillin
  • 1.67 for fluoroquinolones
  • 1.70 for nitrofurantoin/methenamine
  • 1.88 for cephalosporins
  • 2.33 for sulfas

The association was most pronounced among younger children and remained statistically significant for up to five years after exposure, with the exception of broad-spectrum penicillin. The authors concluded that:2

“Oral antibiotics associated with increased odds of nephrolithiasis [kidney stones], with the greatest odds for recent exposure and exposure at younger age. These results have implications for disease pathogenesis and the rising incidence of nephrolithiasis, particularly among children.”

Kidney Stones in Children Are on the Rise

If this link is true, then we’d expect to see rising rates of kidney stones in young patients, and that’s precisely what we’re seeing. As reported by NBC News, July 8, 2023,3 data show kidney stones are “now occurring in younger people, particularly among teenage girls,” and “diets high in ultraprocessed foods” and “increased use of antibiotics early in life” are thought to be among the key contributors to this trend.

Between 1997 and 2012, kidney stones during childhood doubled.

According to research4 published in the Clinical Journal of the American Society of Nephrology in 2016, between 1997 and 2012, the mean annual incidence of kidney stone disease across age groups increased 1% annually, from 206 to 239 per 100,000 persons.

The highest increase was seen in 15- to 19-year-olds, among whom the incidence rate increased 26% per 5 years. Within this age group, incidence was 52% higher among girls. In men, kidney stones became more common after age 25. According to the authors:5

“These changes in incidence resulted in doubling of the risk of nephrolithiasis during childhood and a 45% increase in the lifetime risk of nephrolithiasis for women over the study period.”

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Richard C. Young
Richard C. Young
Richard C. Young is the editor of Young's World Money Forecast, and a contributing editor to both Richardcyoung.com and Youngresearch.com.
Richard C. Young
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