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On his Substack, Jon Rappoport discusses the many times scientists engineering DNA have gotten it all wrong. He writes:
The bright new dawn of genetic engineering of life has a few problems. My, my.
Of course, the engineering companies pitching investors for money downplay the problems, and so do governments. Remember when Biden issued a release glorifying “overwriting cells of the body” (*) to achieve new breakthroughs in…something or other?
From Gene Watch UK, here are documented cases of genetic editing screw-ups. The language is technical, but you can grasp the essentials. Scientists are playing with fire.
“Petri et al. (2022) reported unintended genetic insertions and deletions in zebrafish following prime editing…Prime editing does not induce double stranded breaks and thus is often proposed to be safer than standard CRISPR/Cas systems. Nonetheless, integration of guide RNA derived DNA sequences was detected, showing that even using a technique without introducing foreign DNA, or double-stranded breaks, the technique does not rule out the potential for unintended insertion of exogenous DNA.”
“Tao et al. (2022) reported insertions of transposable elements in human cells in vitro following both standard CRISPR/Cas9 and prime editing systems, though these unintended changes were more common with CRISPR/Cas9 systems. Moreover, hundreds of integrated copies of vector plasmid DNA used to deliver the prime editing machinery were also detected…Moreover, insertions occurred at induced DNA breaks where CRISPR/Cas9 has been applied for controversial therapeutic editing…”
Read more here.
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